Publication List

Tian P; Lindorff-Larsen K; Boomsma W; Jensen MH; Otzen DE, 2016. A Monte Carlo Study of the Early Steps of Functional Amyloid Formation.  PLoS One 11(1):e0146096

Schafer NP; Truong HH; Otzen DE; Lindorff-Larsen K; Wolynes PG, 2016. Topological constraints and modular structure in the folding and functional motions of GlpG, an intramembrane protease.  Proc Natl Acad Sci U S A 113(8):2098-103

Kim JY; Sahu S; Yau YH; Wang X; Shochat SG; Nielsen PH; Dueholm MS; Otzen DE; Lee J; Delos Santos MM; Yam JK; Kang NY; Park SJ; Kwon H; Seviour T; Yang L; Givskov M; Chang YT, 2016. Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11.  J Am Chem Soc 138(1):402-7

Christensen LF; Malmos KG; Christiansen G; Otzen DE, 2016. A complex dance: the importance of glycosaminoglycans and zinc in the aggregation of human prolactin.  Biochemistry.

Kulminskaya NV; Yoshimura Y; Runager K; Sørensen CS; Bjerring M; Andreasen M; Otzen DE; Enghild JJ; Nielsen NC; Mulder FA, 2016. Near-complete (1)H, (13)C, (15)N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T.  Biomol NMR Assign 10(1):25-9

Paslawski W; Lorenzen N; Otzen DE, 2016. Formation and Characterization of α-Synuclein Oligomers.  Methods Mol Biol 1345:133-50

Hjorth CF; Norrman M; Wahlund PO; Benie AJ; Petersen BO; Jessen CM; Pedersen TÅ; Vestergaard K; Steensgaard DB; Pedersen JS; Naver H; Hubálek F; Poulsen C; Otzen D, 2016. Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin.  J Pharm Sci 105(4):1376-86

Scavenius C; Nikolajsen CL; Stenvang M; Thøgersen IB; Wyrożemski Ł; Wisniewski HG; Otzen DE; Sanggaard KW; Enghild JJ, 2016. The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.  J Biol Chem 291(9):4658-70

Stenvang M; Christiansen G; Otzen DE, 2016. Epigallocatechin Gallate Remodels Fibrils of Lattice Corneal Dystrophy Protein, Facilitating Proteolytic Degradation and Preventing Formation of Membrane-Permeabilizing Species.  Biochemistry 55(16):2344-57

Agerschou ED; Christiansen G; Schafer NP; Madsen DJ; Brodersen DE; Semsey S; Otzen DE, 2016. The transcriptional regulator GalR self-assembles to form highly regular tubular structures.  Sci Rep 6:27672

Malmos KG; Bjerring M; Jessen CM; Nielsen EH; Poulsen ET; Christiansen G; Vosegaard T; Skrydstrup T; Enghild JJ; Pedersen JS; Otzen DE, 2016. How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin.  J Biol Chem.

Pantusa M; Vad B; Lillelund O; Kjær L; Otzen D; Bartucci R, 2016. Alpha-synuclein and familial variants affect the chain order and the thermotropic phase behavior of anionic lipid vesicles.  Biochim Biophys Acta.

Madsen JL; Hjørringgaard CU; Vad BS; Otzen D; Skrydstrup T, 2016. Incorporation of β-Silicon-β3-Amino Acids in the Antimicrobial Peptide Alamethicin Provides a 20-Fold Increase in Membrane Permeabilization.  Chemistry 22(24):8358-67

Christiansen JR; Olesen MN; Otzen DE; Romero-Ramos M; Sanchez-Guajardo V, 2016. α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology.  J Neuroinflammation 13(1):74

Frislev HS; Jessen CM; Oliveira CL; Pedersen JS; Otzen DE, 2016. Liprotides made of α-lactalbumin and cis fatty acids form core-shell and multi-layer structures with a common membrane-targeting mechanism.  Biochim Biophys Acta 1864(7):847-59

Vad BS; Balakrishnan VS; Nielsen SB; Otzen DE, 2015. Phospholipid Ether Linkages Significantly Modulate the Membrane Affinity of the Antimicrobial Peptide Novicidin.  J Membr Biol 248(3):487-96

Christoffersen HF; Hansen SK; Vad BS; Nielsen EH; Nielsen JT; Vosegaard T; Skrydstrup T; Otzen DE, 2015. The natural, peptaibolic peptide SPF-5506-A4 adopts a β-bend spiral structure, shows low hemolytic activity and targets membranes through formation of large pores.  Biochim Biophys Acta 1854(8):882-9

Košmrlj A; Cordsen P; Kyrsting A; Otzen DE; Oddershede LB; Jensen MH, 2015. A monomer-trimer model supports intermittent glucagon fibril growth.  Sci Rep 5:9005

Hjorth CF; Hubálek F; Andersson J; Poulsen C; Otzen D; Naver H, 2015. Purification and identification of high molecular weight products formed during storage of neutral formulation of human insulin.  Pharm Res 32(6):2072-85

Madsen JK; Pihl R; Møller AH; Madsen AT; Otzen DE; Andersen KK, 2015. The anionic biosurfactant rhamnolipid does not denature industrial enzymes.  Front Microbiol 6:292

Tian P; Boomsma W; Wang Y; Otzen DE; Jensen MH; Lindorff-Larsen K, 2015. Structure of a functional amyloid protein subunit computed using sequence variation.  J Am Chem Soc 137(1):22-5

Seviour T; Hansen SH; Yang L; Yau YH; Wang VB; Stenvang MR; Christiansen G; Marsili E; Givskov M; Chen Y; Otzen DE; Nielsen PH; Geifman-Shochat S; Kjelleberg S; Dueholm MS, 2015. Functional amyloids keep quorum-sensing molecules in check.  J Biol Chem 290(10):6457-69

Otzen D, 2015. Protein aggregation: close encounters of the greasy kind.  Nat Chem Biol 11(3):176-7

Andreasen M; Lorenzen N; Otzen D, 2015. Interactions between misfolded protein oligomers and membranes: A central topic in neurodegenerative diseases?  Biochim Biophys Acta 1848(9):1897-907

Zeng G; Vad BS; Dueholm MS; Christiansen G; Nilsson M; Tolker-Nielsen T; Nielsen PH; Meyer RL; Otzen DE, 2015. Functional bacterial amyloid increases Pseudomonas biofilm hydrophobicity and stiffness.  Front Microbiol 6:1099

Paslawski W; Lillelund OK; Kristensen JV; Schafer NP; Baker RP; Urban S; Otzen DE, 2015. Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops.  Proc Natl Acad Sci U S A 112(26):7978-83

Michaels TC; Yde P; Willis JC; Jensen MH; Otzen D; Dobson CM; Buell AK; Knowles TP, 2015. The length distribution of frangible biofilaments.  J Chem Phys 143(16):164901

Mohammad-Beigi H; Shojaosadati SA; Marvian AT; Pedersen JN; Klausen LH; Christiansen G; Pedersen JS; Dong M; Morshedi D; Otzen DE, 2015. Strong interactions with polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA NPs) alter α-synuclein conformation and aggregation kinetics.  Nanoscale 7(46):19627-40

Madsen JK; Sørensen TR; Kaspersen JD; Silow MB; Vind J; Pedersen JS; Svendsen A; Otzen DE, 2015. Promoting protein self-association in non-glycosylated Thermomyces lanuginosus lipase based on crystal lattice contacts.  Biochim Biophys Acta 1854(12):1914-21

Dueholm MS; Larsen P; Finster K; Stenvang MR; Christiansen G; Vad BS; Bøggild A; Otzen DE; Nielsen PH, 2015. The Tubular Sheaths Encasing Methanosaeta thermophila Filaments Are Functional Amyloids.  J Biol Chem 290(33):20590-600

Estrela N; Franquelim HG; Lopes C; Tavares E; Macedo JA; Christiansen G; Otzen DE; Melo EP, 2015. Sucrose prevents protein fibrillation through compaction of the tertiary structure but hardly affects the secondary structure.  Proteins 83(11):2039-51

Pedersen JN; Pedersen JS; Otzen DE, 2015. The Use of Liprotides To Stabilize and Transport Hydrophobic Molecules.  Biochemistry 54(31):4815-23

Christoffersen HF; Andreasen M; Zhang S; Nielsen EH; Christiansen G; Dong M; Skrydstrup T; Otzen DE, 2015. Scaffolded multimers of hIAPP(20-29) peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP(20-29) peptide fragment.  Biochim Biophys Acta 1854(12):1890-7

Knudsen AD; Bennike T; Kjeldal H; Birkelund S; Otzen DE; Stensballe A, 2014. Condenser: a statistical aggregation tool for multi-sample quantitative proteomic data from Matrix Science Mascot Distiller™.  J Proteomics 103:261-6

Andersen KK; Otzen DE, 2014. Folding of outer membrane protein A in the anionic biosurfactant rhamnolipid.  FEBS Lett 588(10):1955-60

Lorenzen N; Nielsen SB; Buell AK; Kaspersen JD; Arosio P; Vad BS; Paslawski W; Christiansen G; Valnickova-Hansen Z; Andreasen M; Enghild JJ; Pedersen JS; Dobson CM; Knowles TP; Otzen DE, 2014. The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.  J Am Chem Soc 136(10):3859-68

Paslawski W; Mysling S; Thomsen K; Jørgensen TJ; Otzen DE, 2014. Co-existence of two different α-synuclein oligomers with different core structures determined by hydrogen/deuterium exchange mass spectrometry.  Angew Chem Int Ed Engl 53(29):7560-3

Poulsen ET; Runager K; Risør MW; Dyrlund TF; Scavenius C; Karring H; Praetorius J; Vorum H; Otzen DE; Klintworth GK; Enghild JJ, 2014. Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene.  Proteomics Clin Appl 8(3-4):168-77

Skals M; Bjaelde RG; Reinholdt J; Poulsen K; Vad BS; Otzen DE; Leipziger J; Praetorius HA, 2014. Bacterial RTX toxins allow acute ATP release from human erythrocytes directly through the toxin pore.  J Biol Chem 289(27):19098-109

Lopes P; Dyrnesli H; Lorenzen N; Otzen D; Ferapontova EE, 2014. Electrochemical analysis of the fibrillation of Parkinson's disease α-synuclein.  Analyst 139(4):749-56

Lorenzen N; Lemminger L; Pedersen JN; Nielsen SB; Otzen DE, 2014. The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes.  FEBS Lett 588(3):497-502

Kronqvist N; Otikovs M; Chmyrov V; Chen G; Andersson M; Nordling K; Landreh M; Sarr M; Jörnvall H; Wennmalm S; Widengren J; Meng Q; Rising A; Otzen D; Knight SD; Jaudzems K; Johansson J, 2014. Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation.  Nat Commun 5:3254

Neumann J; Klein N; Otzen DE; Schneider D, 2014. Folding energetics and oligomerization of polytopic α-helical transmembrane proteins.  Arch Biochem Biophys 564:281-96

Kaspersen JD; Pedersen JN; Hansted JG; Nielsen SB; Sakthivel S; Wilhelm K; Nemashkalova EL; Permyakov SE; Permyakov EA; Pinto Oliveira CL; Morozova-Roche LA; Otzen DE; Pedersen JS, 2014. Generic structures of cytotoxic liprotides: nano-sized complexes with oleic acid cores and shells of disordered proteins.  Chembiochem 15(18):2693-702

Otzen D, 2014. Membrane protein folding and stability.  Arch Biochem Biophys 564:262-4

Lorenzen N; Nielsen SB; Yoshimura Y; Vad BS; Andersen CB; Betzer C; Kaspersen JD; Christiansen G; Pedersen JS; Jensen PH; Mulder FA; Otzen DE, 2014. How epigallocatechin gallate can inhibit α-synuclein oligomer toxicity in vitro.  J Biol Chem 289(31):21299-310

Andreasen M; Skeby KK; Zhang S; Nielsen EH; Klausen LH; Frahm H; Christiansen G; Skrydstrup T; Dong M; Schiøtt B; Otzen D, 2014. The importance of being capped: Terminal capping of an amyloidogenic peptide affects fibrillation propensity and fibril morphology.  Biochemistry 53(44):6968-80

Andersen KK; Otzen DE, 2014. Denaturation of α-lactalbumin and myoglobin by the anionic biosurfactant rhamnolipid.  Biochim Biophys Acta 1844(12):2338-2345

Hyldgaard M; Mygind T; Vad BS; Stenvang M; Otzen DE; Meyer RL, 2014. The antimicrobial mechanism of action of epsilon-poly-l-lysine.  Appl Environ Microbiol 80(24):7758-70

Døvling Kaspersen J; Moestrup Jessen C; Stougaard Vad B; Skipper Sørensen E; Kleiner Andersen K; Glasius M; Pinto Oliveira CL; Otzen DE; Pedersen JS, 2014. Low-resolution structures of OmpA⋅DDM protein-detergent complexes.  Chembiochem 15(14):2113-24

Lorenzen N; Otzen DE, 2014. Oligomers of α-synuclein: picking the culprit in the line-up.  Essays Biochem 56:137-48

Paslawski W; Andreasen M; Nielsen SB; Lorenzen N; Thomsen K; Kaspersen JD; Pedersen JS; Otzen DE, 2014. High stability and cooperative unfolding of α-synuclein oligomers.  Biochemistry 53(39):6252-63

Deva T; Lorenzen N; Vad BS; Petersen SV; Thørgersen I; Enghild JJ; Kristensen T; Otzen DE, 2013. Off-pathway aggregation can inhibit fibrillation at high protein concentrations.  Biochim Biophys Acta 1834(3):677-87

Wang H; Hagedorn J; Svendsen A; Borch K; Otzen DE, 2013. Variant of the Thermomyces lanuginosus lipase with improved kinetic stability: a candidate for enzyme replacement therapy.  Biophys Chem 172:43-52

Wang H; Andersen KK; Sehgal P; Hagedorn J; Westh P; Borch K; Otzen DE, 2013. pH regulation of the kinetic stability of the lipase from Thermomyces lanuginosus.  Biochemistry 52(1):264-76

Zhang S; Andreasen M; Nielsen JT; Liu L; Nielsen EH; Song J; Ji G; Sun F; Skrydstrup T; Besenbacher F; Nielsen NC; Otzen DE; Dong M, 2013. Coexistence of ribbon and helical fibrils originating from hIAPP(20-29) revealed by quantitative nanomechanical atomic force microscopy.  Proc Natl Acad Sci U S A 110(8):2798-803

Wang H; Andersen KK; Vad BS; Otzen DE, 2013. OmpA can form folded and unfolded oligomers.  Biochim Biophys Acta 1834(1):127-36

Nielsen SB; Otzen DE, 2013. Quartz crystal microbalances as tools for probing protein-membrane interactions.  Methods Mol Biol 974:1-21

Otzen DE; Andersen KK, 2013. Folding of outer membrane proteins.  Arch Biochem Biophys 531(1-2):34-43

Helwig M; Hoshino A; Berridge C; Lee SN; Lorenzen N; Otzen DE; Eriksen JL; Lindberg I, 2013. The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.  J Biol Chem 288(2):1114-24

Balakrishnan VS; Vad BS; Otzen DE, 2013. Novicidin's membrane permeabilizing activity is driven by membrane partitioning but not by helicity: a biophysical study of the impact of lipid charge and cholesterol.  Biochim Biophys Acta 1834(6):996-1002

Abelein A; Kaspersen JD; Nielsen SB; Jensen GV; Christiansen G; Pedersen JS; Danielsson J; Otzen DE; Gräslund A, 2013. Formation of dynamic soluble surfactant-induced amyloid β peptide aggregation intermediates.  J Biol Chem 288(32):23518-28

Nielsen SB; Macchi F; Raccosta S; Langkilde AE; Giehm L; Kyrsting A; Svane AS; Manno M; Christiansen G; Nielsen NC; Oddershede L; Vestergaard B; Otzen DE, 2013. Wildtype and A30P mutant alpha-synuclein form different fibril structures.  PLoS One 8(7):e67713

Dueholm MS; Otzen D; Nielsen PH, 2013. Evolutionary insight into the functional amyloids of the pseudomonads.  PLoS One 8(10):e76630

Cohen SI; Linse S; Luheshi LM; Hellstrand E; White DA; Rajah L; Otzen DE; Vendruscolo M; Dobson CM; Knowles TP, 2013. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.  Proc Natl Acad Sci U S A 110(24):9758-63

Brinkmann CR; Thiel S; Otzen DE, 2013. Protein-fatty acid complexes: biochemistry, biophysics and function.  FEBS J 280(8):1733-49

Pigolotti S; Lizana L; Otzen D; Sneppen K, 2013. Quality control system response to stochastic growth of amyloid fibrils.  FEBS Lett 587(9):1405-10

Dueholm MS; Søndergaard MT; Nilsson M; Christiansen G; Stensballe A; Overgaard MT; Givskov M; Tolker-Nielsen T; Otzen DE; Nielsen PH, 2013. Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation.  Microbiologyopen 2(3):365-82

Underhaug J; Koldsø H; Runager K; Nielsen JT; Sørensen CS; Kristensen T; Otzen DE; Karring H; Malmendal A; Schiøtt B; Enghild JJ; Nielsen NC, 2013. Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilization.  Biochim Biophys Acta 1834(12):2812-22

Otzen D, 2012. N for AsN - O for strOcture? A strand-loop-strand motif for prokaryotic O-glycosylation.  Mol Microbiol 83(5):879-83

Nielsen SB; Yde P; Giehm L; Sundbye S; Christiansen G; Mathiesen J; Jensen MH; Jensen PH; Otzen DE, 2012. Multiple roles of heparin in the aggregation of p25α.  J Mol Biol 421(4-5):601-15

Macchi F; Eisenkolb M; Kiefer H; Otzen DE, 2012. The effect of osmolytes on protein fibrillation.  Int J Mol Sci 13(3):3801-19

Ghodke S; Nielsen SB; Christiansen G; Hjuler HA; Flink J; Otzen D, 2012. Mapping out the multistage fibrillation of glucagon.  FEBS J 279(5):752-65

Pedersen LR; Nielsen SB; Hansted JG; Petersen TE; Otzen DE; Sørensen ES, 2012. PP3 forms stable tetrameric structures through hydrophobic interactions via the C-terminal amphipathic helix and undergoes reversible thermal dissociation and denaturation.  FEBS J 279(2):336-47

Weber M; Tome L; Otzen D; Schneider D, 2012. A Ser residue influences the structure and stability of a Pro-kinked transmembrane helix dimer.  Biochim Biophys Acta 1818(9):2103-7

Andreasen M; Nielsen SB; Mittag T; Bjerring M; Nielsen JT; Zhang S; Nielsen EH; Jeppesen M; Christiansen G; Besenbacher F; Dong M; Nielsen NC; Skrydstrup T; Otzen DE, 2012. Modulation of fibrillation of hIAPP core fragments by chemical modification of the peptide backbone.  Biochim Biophys Acta 1824(2):274-85

Otzen DE; Blans K; Wang H; Gilbert GE; Rasmussen JT, 2012. Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition.  Biochim Biophys Acta 1818(4):1019-27

Otzen D, 2012. The role of proteins in biosilicification.  Scientifica (Cairo) 2012:867562

Calcutta A; Jessen CM; Behrens MA; Oliveira CL; Renart ML; González-Ros JM; Otzen DE; Pedersen JS; Malmendal A; Nielsen NC, 2012. Mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques: TFE-induced unfolding of KcsA in DDM surfactant.  Biochim Biophys Acta 1818(9):2290-301

Andreasen M; Nielsen SB; Runager K; Christiansen G; Nielsen NC; Enghild JJ; Otzen DE, 2012. Polymorphic fibrillation of the destabilized fourth fasciclin-1 domain mutant A546T of the Transforming growth factor-β-induced protein (TGFBIp) occurs through multiple pathways with different oligomeric intermediates.  J Biol Chem 287(41):34730-42

Oeemig JS; Lynggaard C; Knudsen DH; Hansen FT; Nørgaard KD; Schneider T; Vad BS; Sandvang DH; Nielsen LA; Neve S; Kristensen HH; Sahl HG; Otzen DE; Wimmer R, 2012. Eurocin, a new fungal defensin: structure, lipid binding, and its mode of action.  J Biol Chem 287(50):42361-72

Dueholm MS; Albertsen M; Otzen D; Nielsen PH, 2012. Curli functional amyloid systems are phylogenetically widespread and display large diversity in operon and protein structure.  PLoS One 7(12):e51274

Lorenzen N; Cohen SI; Nielsen SB; Herling TW; Christiansen G; Dobson CM; Knowles TP; Otzen D, 2012. Role of elongation and secondary pathways in S6 amyloid fibril growth.  Biophys J 102(9):2167-75

Andersen KK; Wang H; Otzen DE, 2012. A kinetic analysis of the folding and unfolding of OmpA in urea and guanidinium chloride: single and parallel pathways.  Biochemistry 51(42):8371-83

Kalashnyk N; Nielsen JT; Nielsen EH; Skrydstrup T; Otzen DE; Lægsgaard E; Wang C; Besenbacher F; Nielsen NC; Linderoth TR, 2012. Scanning tunneling microscopy reveals single-molecule insights into the self-assembly of amyloid fibrils.  ACS Nano 6(8):6882-9

Hjørringgaard CU; Vad BS; Matchkov VV; Nielsen SB; Vosegaard T; Nielsen NC; Otzen DE; Skrydstrup T, 2012. Cyclodextrin-scaffolded alamethicin with remarkably efficient membrane permeabilizing properties and membrane current conductance.  J Phys Chem B 116(26):7652-9

Pedersen LR; Hansted JG; Nielsen SB; Petersen TE; Sørensen US; Otzen D; Sørensen ES, 2012. Proteolytic activation of proteose peptone component 3 by release of a C-terminal peptide with antibacterial properties.  J Dairy Sci 95(6):2819-29

Giehm L; Svergun DI; Otzen DE; Vestergaard B, 2011. Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation.  Proc Natl Acad Sci U S A 108(8):3246-51

Bertelsen K; Vad B; Nielsen EH; Hansen SK; Skrydstrup T; Otzen DE; Vosegaard T; Nielsen NC, 2011. Long-term-stable ether-lipid vs conventional ester-lipid bicelles in oriented solid-state NMR: altered structural information in studies of antimicrobial peptides.  J Phys Chem B 115(8):1767-74

Weber M; Prodöhl A; Dreher C; Becker C; Underhaug J; Svane AS; Malmendal A; Nielsen NC; Otzen D; Schneider D, 2011. SDS-facilitated in vitro formation of a transmembrane B-type cytochrome is mediated by changes in local pH.  J Mol Biol 407(4):594-606

Giehm L; Lorenzen N; Otzen DE, 2011. Assays for α-synuclein aggregation.  Methods 53(3):295-305

Debnath DK; Basaiawmoit RV; Nielsen KL; Otzen DE, 2011. The role of membrane properties in Mistic folding and dimerisation.  Protein Eng Des Sel 24(1-2):89-97

Basaiawmoit RV; Oliveira CL; Runager K; Sørensen CS; Behrens MA; Jonsson BH; Kristensen T; Klintworth GK; Enghild JJ; Pedersen JS; Otzen DE, 2011. SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutation.  J Mol Biol 408(3):503-13

Otzen DE, 2011. Mapping the folding pathway of the transmembrane protein DsbB by protein engineering.  Protein Eng Des Sel 24(1-2):139-49

Runager K; Basaiawmoit RV; Deva T; Andreasen M; Valnickova Z; Sørensen CS; Karring H; Thøgersen IB; Christiansen G; Underhaug J; Kristensen T; Nielsen NC; Klintworth GK; Otzen DE; Enghild JJ, 2011. Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp.  J Biol Chem 286(7):4951-8

Wang J; Jensen UB; Jensen GV; Shipovskov S; Balakrishnan VS; Otzen D; Pedersen JS; Besenbacher F; Sutherland DS, 2011. Soft interactions at nanoparticles alter protein function and conformation in a size dependent manner.  Nano Lett 11(11):4985-91

Otzen DE, 2011. Assembling good amyloid: some structures at last.  Structure 19(9):1207-9

Otzen D, 2011. Protein-surfactant interactions: a tale of many states.  Biochim Biophys Acta 1814(5):562-91

Macchi F; Hoffmann SV; Carlsen M; Vad B; Imparato A; Rischel C; Otzen DE, 2011. Mechanical stress affects glucagon fibrillation kinetics and fibril structure.  Langmuir 27(20):12539-49

Scavenius C; Ghodke S; Otzen DE; Enghild JJ, 2011. Hydrogen exchange mass spectrometry as an analytical tool for the analysis of amyloid fibrillogenesis.  Int J Mass Spectrom 302(1-3):167-173

Hansted JG; Wejse PL; Bertelsen H; Otzen DE, 2011. Effect of protein-surfactant interactions on aggregation of β-lactoglobulin.  Biochim Biophys Acta 1814(5):713-23

Du XT; Wang L; Wang YJ; Andreasen M; Zhan DW; Feng Y; Li M; Zhao M; Otzen D; Xue D; Yang Y; Liu RT, 2011. Aβ1-16 can aggregate and induce the production of reactive oxygen species, nitric oxide, and inflammatory cytokines.  J Alzheimers Dis 27(2):401-13

Dueholm MS; Nielsen SB; Hein KL; Nissen P; Chapman M; Christiansen G; Nielsen PH; Otzen DE, 2011. Fibrillation of the major curli subunit CsgA under a wide range of conditions implies a robust design of aggregation.  Biochemistry 50(39):8281-90

Vad BS; Bertelsen K; Johansen CH; Pedersen JM; Skrydstrup T; Nielsen NC; Otzen DE, 2010. Pardaxin permeabilizes vesicles more efficiently by pore formation than by disruption.  Biophys J 98(4):576-85

Malmendal A; Underhaug J; Otzen DE; Nielsen NC, 2010. Fast mapping of global protein folding states by multivariate NMR: a GPS for proteins.  PLoS One 5(4):e10262

Nielsen SB; Wilhelm K; Vad B; Schleucher J; Morozova-Roche LA; Otzen D, 2010. The interaction of equine lysozyme:oleic acid complexes with lipid membranes suggests a cargo off-loading mechanism.  J Mol Biol 398(2):351-61

Hein KL; Kragh-Hansen U; Morth JP; Jeppesen MD; Otzen D; Møller JV; Nissen P, 2010. Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin.  J Struct Biol 171(3):353-60

Andersen CB; Hicks MR; Vetri V; Vandahl B; Rahbek-Nielsen H; Thøgersen H; Thøgersen IB; Enghild JJ; Serpell LC; Rischel C; Otzen DE, 2010. Glucagon fibril polymorphism reflects differences in protofilament backbone structure.  J Mol Biol 397(4):932-46

Debnath D; Nielsen KL; Otzen DE, 2010. In vitro association of fragments of a beta-sheet membrane protein.  Biophys Chem 148(1-3):112-20

Jeppesen MD; Westh P; Otzen DE, 2010. The role of protonation in protein fibrillation.  FEBS Lett 584(4):780-4

Kiliç NK; Stensballe A; Otzen DE; Dönmez G, 2010. Proteomic changes in response to chromium(VI) toxicity in Pseudomonas aeruginosa.  Bioresour Technol 101(7):2134-40

Vad B; Thomsen LA; Bertelsen K; Franzmann M; Pedersen JM; Nielsen SB; Vosegaard T; Valnickova Z; Skrydstrup T; Enghild JJ; Wimmer R; Nielsen NC; Otzen DE, 2010. Divorcing folding from function: how acylation affects the membrane-perturbing properties of an antimicrobial peptide.  Biochim Biophys Acta 1804(4):806-20

Reinau ME; Thøgersen IB; Enghild JJ; Nielsen KL; Otzen DE, 2010. The diversity of FtsY-lipid interactions.  Biopolymers 93(7):595-606

Giehm L; Otzen DE, 2010. Strategies to increase the reproducibility of protein fibrillization in plate reader assays.  Anal Biochem 400(2):270-81

Nielsen SB; Otzen DE, 2010. Impact of the antimicrobial peptide Novicidin on membrane structure and integrity.  J Colloid Interface Sci 345(2):248-56

Nielsen SB; Franzmann M; Basaiawmoit RV; Wimmer R; Mikkelsen JD; Otzen DE, 2010. beta-Sheet aggregation of kisspeptin-10 is stimulated by heparin but inhibited by amphiphiles.  Biopolymers 93(8):678-89

Ferkinghoff-Borg J; Fonslet J; Andersen CB; Krishna S; Pigolotti S; Yagi H; Goto Y; Otzen D; Jensen MH, 2010. Stop-and-go kinetics in amyloid fibrillation.  Phys Rev E Stat Nonlin Soft Matter Phys 82(1 Pt 1):010901

Debnath DK; Otzen DE, 2010. Cell-free synthesis and folding of transmembrane OmpA reveals higher order structures and premature truncations.  Biophys Chem 152(1-3):80-8

Valnickova Z; Sanglas L; Arolas JL; Petersen SV; Schar C; Otzen D; Aviles FX; Gomis-Rüth FX; Enghild JJ, 2010. Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates.  J Biol Chem 285(49):38243-50

Pedersen JS; Andersen CB; Otzen DE, 2010. Amyloid structure--one but not the same: the many levels of fibrillar polymorphism.  FEBS J 277(22):4591-601

Otzen DE, 2010. Amyloid formation in surfactants and alcohols: membrane mimetics or structural switchers?  Curr Protein Pept Sci 11(5):355-71

Dorosz J; Gofman Y; Kolusheva S; Otzen D; Ben-Tal N; Nielsen NC; Jelinek R, 2010. Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion.  J Phys Chem B 114(34):11053-60

Otzen D, 2010. Functional amyloid: turning swords into plowshares.  Prion 4(4):256-64

Giehm L; Dal Degan F; Fraser P; Klysner S; Otzen DE, 2010. An Aß concatemer with altered aggregation propensities.  Biochim Biophys Acta 1804(10):2025-35

Jeppesen MD; Hein K; Nissen P; Westh P; Otzen DE, 2010. A thermodynamic analysis of fibrillar polymorphism.  Biophys Chem 149(1-2):40-6

Triano I; Barrera FN; Renart ML; Molina ML; Fernández-Ballester G; Poveda JA; Fernández AM; Encinar JA; Ferrer-Montiel AV; Otzen D; González-Ros JM, 2010. Occupancy of nonannular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein.  Biochemistry 49(25):5397-404

Dueholm MS; Petersen SV; Sønderkær M; Larsen P; Christiansen G; Hein KL; Enghild JJ; Nielsen JL; Nielsen KL; Nielsen PH; Otzen DE, 2010. Functional amyloid in Pseudomonas.  Mol Microbiol 77(4):1009-20

Giehm L; Oliveira CL; Christiansen G; Pedersen JS; Otzen DE, 2010. SDS-induced fibrillation of alpha-synuclein: an alternative fibrillation pathway.  J Mol Biol 401(1):115-33

Andersen CB; Yagi H; Manno M; Martorana V; Ban T; Christiansen G; Otzen DE; Goto Y; Rischel C, 2009. Branching in amyloid fibril growth.  Biophys J 96(4):1529-36

Kjaer L; Giehm L; Heimburg T; Otzen D, 2009. The influence of vesicle size and composition on alpha-synuclein structure and stability.  Biophys J 96(7):2857-70

Huynh TH; Mantel ML; Mikkelsen K; Lindhardt AT; Nielsen NC; Otzen D; Skrydstrup T, 2009. A versatile approach to beta-amyloid fibril-binding compounds exploiting the Shirakawa/Hayashi protocol for trans-alkene synthesis.  Org Lett 11(4):999-1002

Oliveira CL; Behrens MA; Pedersen JS; Erlacher K; Otzen D; Pedersen JS, 2009. A SAXS study of glucagon fibrillation.  J Mol Biol 387(1):147-61

Otzen DE; Sehgal P; Westh P, 2009. Alpha-Lactalbumin is unfolded by all classes of surfactants but by different mechanisms.  J Colloid Interface Sci 329(2):273-83

Jordal PB; Dueholm MS; Larsen P; Petersen SV; Enghild JJ; Christiansen G; Højrup P; Nielsen PH; Otzen DE, 2009. Widespread abundance of functional bacterial amyloid in mycolata and other gram-positive bacteria.  Appl Environ Microbiol 75(12):4101-10

Nesgaard L; Vad B; Christiansen G; Otzen D, 2009. Kinetic partitioning between aggregation and vesicle permeabilization by modified ADan.  Biochim Biophys Acta 1794(1):84-93

Hansen JH; Petersen SV; Andersen KK; Enghild JJ; Damhus T; Otzen D, 2009. Stable intermediates determine proteins' primary unfolding sites in the presence of surfactants.  Biopolymers 91(3):221-31

Nielsen JT; Bjerring M; Jeppesen MD; Pedersen RO; Pedersen JM; Hein KL; Vosegaard T; Skrydstrup T; Otzen DE; Nielsen NC, 2009. Unique identification of supramolecular structures in amyloid fibrils by solid-state NMR spectroscopy.  Angew Chem Int Ed Engl 48(12):2118-21

Andersen KK; Oliveira CL; Larsen KL; Poulsen FM; Callisen TH; Westh P; Pedersen JS; Otzen D, 2009. The role of decorated SDS micelles in sub-CMC protein denaturation and association.  J Mol Biol 391(1):207-26

Andersen KK; Otzen DE, 2009. How chain length and charge affect surfactant denaturation of acyl coenzyme A binding protein (ACBP).  J Phys Chem B 113(42):13942-52

Sneppen K; Lizana L; Jensen MH; Pigolotti S; Otzen D, 2009. Modeling proteasome dynamics in Parkinson's disease.  Phys Biol 6(3):036005

Rantalainen KI; Christensen PA; Hafrén A; Otzen DE; Kalkkinen N; Mäkinen K, 2009. Interaction of a potyviral VPg with anionic phospholipid vesicles.  Virology 395(1):114-20

Mittag T; Otzen DE; Nielsen NC; Skrydstrup T, 2009. Synthesis of a ketomethylene isostere of the fibrillating peptide SNNFGAILSS.  J Org Chem 74(20):7955-7

Reinau ME; Otzen DE, 2009. Stability and structure of the membrane protein transporter Ffh is modulated by substrates and lipids.  Arch Biochem Biophys 492(1-2):48-53

Li Y; Dong M; Otzen DE; Yao Y; Liu B; Besenbacher F; Mamdouh W, 2009. Influence of tunable external stimuli on the self-assembly of guanosine supramolecular nanostructures studied by atomic force microscope.  Langmuir 25(23):13432-7

Cabré EJ; Malmström J; Sutherland D; Pérez-Gil J; Otzen DE, 2009. Surfactant protein SP-B strongly modifies surface collapse of phospholipid vesicles: insights from a quartz crystal microbalance with dissipation.  Biophys J 97(3):768-76

Franzmann M; Otzen D; Wimmer R, 2009. Quantitative use of paramagnetic relaxation enhancements for determining orientations and insertion depths of peptides in micelles.  Chembiochem 10(14):2339-47

Larsen P; Nielsen JL; Otzen D; Nielsen PH, 2008. Amyloid-like adhesins produced by floc-forming and filamentous bacteria in activated sludge.  Appl Environ Microbiol 74(5):1517-26

Giehm L; Christensen C; Boas U; Heegaard PM; Otzen DE, 2008. Dendrimers destabilize proteins in a generation-dependent manner involving electrostatic interactions.  Biopolymers 89(6):522-9

Otzen DE; Nesgaard LW; Andersen KK; Hansen JH; Christiansen G; Doe H; Sehgal P, 2008. Aggregation of S6 in a quasi-native state by sub-micellar SDS.  Biochim Biophys Acta 1784(2):400-14

Otzen D; Nielsen PH, 2008. We find them here, we find them there: functional bacterial amyloid.  Cell Mol Life Sci 65(6):910-27

Baptista RP; Pedersen S; Cabrita GJ; Otzen DE; Cabral JM; Melo EP, 2008. Thermodynamics and mechanism of cutinase stabilization by trehalose.  Biopolymers 89(6):538-47

Pedersen JS; Otzen DE, 2008. Amyloid-a state in many guises: survival of the fittest fibril fold.  Protein Sci 17(1):2-10

Andersen KK; Westh P; Otzen DE, 2008. Global study of myoglobin-surfactant interactions.  Langmuir 24(2):399-407

Dong M; Hovgaard MB; Mamdouh W; Xu S; Otzen DE; Besenbacher F, 2008. AFM-based force spectroscopy measurements of mature amyloid fibrils of the peptide glucagon.  Nanotechnology 19(38):384013

Haaning S; Radutoiu S; Hoffmann SV; Dittmer J; Giehm L; Otzen DE; Stougaard J, 2008. An unusual intrinsically disordered protein from the model legume Lotus japonicus stabilizes proteins in vitro.  J Biol Chem 283(45):31142-52

Otzen D, 2008. Differential adsorption of variants of the Thermomyces lanuginosus lipase on a hydrophobic surface suggests a role for local flexibility.  Colloids Surf B Biointerfaces 64(2):223-8

Christensen PA; Pedersen JS; Christiansen G; Otzen DE, 2008. Spectroscopic evidence for the existence of an obligate pre-fibrillar oligomer during glucagon fibrillation.  FEBS Lett 582(9):1341-5

Nesgaard LW; Hoffmann SV; Andersen CB; Malmendal A; Otzen DE, 2008. Characterization of dry globular proteins and protein fibrils by synchrotron radiation vacuum UV circular dichroism.  Biopolymers 89(9):779-95

Knudsen SK; Stensballe A; Franzmann M; Westergaard UB; Otzen DE, 2008. Effect of glycosylation on the extracellular domain of the Ag43 bacterial autotransporter: enhanced stability and reduced cellular aggregation.  Biochem J 412(3):563-77

Svane AS; Jahn K; Deva T; Malmendal A; Otzen DE; Dittmer J; Nielsen NC, 2008. Early stages of amyloid fibril formation studied by liquid-state NMR: the peptide hormone glucagon.  Biophys J 95(1):366-77

Otzen DE; Sehgal P; Nesgaard LW, 2007. Alternative membrane protein conformations in alcohols.  Biochemistry 46(14):4348-59

Nielsen MM; Andersen KK; Westh P; Otzen DE, 2007. Unfolding of beta-sheet proteins in SDS.  Biophys J 92(10):3674-85

Otzen DE; Giehm L; Baptista RP; Kristensen SR; Melo EP; Pedersen S, 2007. Aggregation as the basis for complex behaviour of cutinase in different denaturants.  Biochim Biophys Acta 1774(2):323-33

Hovgaard MB; Dong M; Otzen DE; Besenbacher F, 2007. Quartz crystal microbalance studies of multilayer glucagon fibrillation at the solid-liquid interface.  Biophys J 93(6):2162-9

Valnickova Z; Petersen SV; Nielsen SB; Otzen DE; Enghild JJ, 2007. Heparin binding induces a conformational change in pigment epithelium-derived factor.  J Biol Chem 282(9):6661-7

Mogensen JE; Ferreras M; Wimmer R; Petersen SV; Enghild JJ; Otzen DE, 2007. The major allergen from birch tree pollen, Bet v 1, binds and permeabilizes membranes.  Biochemistry 46(11):3356-65

Heegaard PM; Boas U; Otzen DE, 2007. Dendrimer effects on peptide and protein fibrillation.  Macromol Biosci 7(8):1047-59

Andersen CB; Otzen D; Christiansen G; Rischel C, 2007. Glucagon amyloid-like fibril morphology is selected via morphology-dependent growth inhibition.  Biochemistry 46(24):7314-24

Dalsgaard TK; Otzen D; Nielsen JH; Larsen LB, 2007. Changes in structures of milk proteins upon photo-oxidation.  J Agric Food Chem 55(26):10968-76

Sehgal P; Bang Nielsen S; Pedersen S; Wimmer R; Otzen DE, 2007. Modulation of cutinase stability and structure by phospholipid detergents.  Biochim Biophys Acta 1774(12):1544-54

Larsen P; Nielsen JL; Dueholm MS; Wetzel R; Otzen D; Nielsen PH, 2007. Amyloid adhesins are abundant in natural biofilms.  Environ Microbiol 9(12):3077-90

Song YJ; Lundvig DM; Huang Y; Gai WP; Blumbergs PC; Højrup P; Otzen D; Halliday GM; Jensen PH, 2007. p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy.  Am J Pathol 171(4):1291-303

Holm NK; Jespersen SK; Thomassen LV; Wolff TY; Sehgal P; Thomsen LA; Christiansen G; Andersen CB; Knudsen AD; Otzen DE, 2007. Aggregation and fibrillation of bovine serum albumin.  Biochim Biophys Acta 1774(9):1128-38

Pedersen JS; Flink JM; Dikov D; Otzen DE, 2006. Sulfates dramatically stabilize a salt-dependent type of glucagon fibrils.  Biophys J 90(11):4181-94

Chen L; Ferreira JA; Costa SM; Cabrita GJ; Otzen DE; Melo EP, 2006. Compaction of ribosomal protein S6 by sucrose occurs only under native conditions.  Biochemistry 45(7):2189-99

Pedersen JS; Dikov D; Flink JL; Hjuler HA; Christiansen G; Otzen DE, 2006. The changing face of glucagon fibrillation: structural polymorphism and conformational imprinting.  J Mol Biol 355(3):501-23

Wimmer R; Andersen KK; Vad B; Davidsen M; Mølgaard S; Nesgaard LW; Kristensen HH; Otzen DE, 2006. Versatile interactions of the antimicrobial peptide novispirin with detergents and lipids.  Biochemistry 45(2):481-97

Sehgal P; Otzen DE, 2006. Thermodynamics of unfolding of an integral membrane protein in mixed micelles.  Protein Sci 15(4):890-9

Pedersen JS; Dikov D; Otzen DE, 2006. N- and C-terminal hydrophobic patches are involved in fibrillation of glucagon.  Biochemistry 45(48):14503-12

Pedersen S; Nesgaard L; Baptista RP; Melo EP; Kristensen SR; Otzen DE, 2006. pH-dependent aggregation of cutinase is efficiently suppressed by 1,8-ANS.  Biopolymers 83(6):619-29

Finger C; Volkmer T; Prodöhl A; Otzen DE; Engelman DM; Schneider D, 2006. The stability of transmembrane helix interactions measured in a biological membrane.  J Mol Biol 358(5):1221-8

Dong M; Hovgaard MB; Xu S; Otzen DE; Besenbacher F, 2006. AFM study of glucagon fibrillation via oligomeric structures resulting in interwoven fibrils.  Nanotechnology 17(16):4003-9

Otzen DE; Lundvig DM; Wimmer R; Nielsen LH; Pedersen JR; Jensen PH, 2005. p25alpha is flexible but natively folded and binds tubulin with oligomeric stoichiometry.  Protein Sci 14(6):1396-409

Frokjaer S; Otzen DE, 2005. Protein drug stability: a formulation challenge.  Nat Rev Drug Discov 4(4):298-306

Lindersson E; Lundvig D; Petersen C; Madsen P; Nyengaard JR; Højrup P; Moos T; Otzen D; Gai WP; Blumbergs PC; Jensen PH, 2005. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.  J Biol Chem 280(7):5703-15

Otzen DE, 2005. Conformational detours during folding of a collapsed state.  Biochim Biophys Acta 1750(2):146-53

Mogensen JE; Sehgal P; Otzen DE, 2005. Activation, inhibition, and destabilization of Thermomyces lanuginosus lipase by detergents.  Biochemistry 44(5):1719-30

Mogensen JE; Tapadar D; Schmidt MA; Otzen DE, 2005. Barriers to folding of the transmembrane domain of the Escherichia coli autotransporter adhesin involved in diffuse adherence.  Biochemistry 44(11):4533-45

Mogensen JE; Otzen DE, 2005. Interactions between folding factors and bacterial outer membrane proteins.  Mol Microbiol 57(2):326-46

Mogensen JE; Kleinschmidt JH; Schmidt MA; Otzen DE, 2005. Misfolding of a bacterial autotransporter.  Protein Sci 14(11):2814-27

Sehgal P; Mogensen JE; Otzen DE, 2005. Using micellar mole fractions to assess membrane protein stability in mixed micelles.  Biochim Biophys Acta 1716(1):59-68

Chen L; Cabrita GJ; Otzen DE; Melo EP, 2005. Stabilization of the ribosomal protein S6 by trehalose is counterbalanced by the formation of a putative off-pathway species.  J Mol Biol 351(2):402-16

Otzen D, 2005. Antagonism, non-native interactions and non-two-state folding in S6 revealed by double-mutant cycle analysis.  Protein Eng Des Sel 18(11):547-57

Otzen DE; Oliveberg M, 2004. Transient formation of nano-crystalline structures during fibrillation of an Abeta-like peptide.  Protein Sci 13(5):1417-21

Mogensen JE; Ipsen H; Holm J; Otzen DE, 2004. Elimination of a misfolded folding intermediate by a single point mutation.  Biochemistry 43(12):3357-67

Pedersen JS; Christensen G; Otzen DE, 2004. Modulation of S6 fibrillation by unfolding rates and gatekeeper residues.  J Mol Biol 341(2):575-88

Justesen PH; Kristensen T; Ebdrup T; Otzen D, 2004. Investigating porcine pancreatic phospholipase A2 action on vesicles and supported planar bilayers using a quartz crystal microbalance with dissipation.  J Colloid Interface Sci 279(2):399-409

Otzen DE; Miron S; Akke M; Oliveberg M, 2004. Transient aggregation and stable dimerization induced by introducing an Alzheimer sequence into a water-soluble protein.  Biochemistry 43(41):12964-78

Otzen DE; Oliveberg M, 2004. Correspondence between anomalous m- and DeltaCp-values in protein folding.  Protein Sci 13(12):3253-63

Melo EP; Chen L; Cabral JM; Fojan P; Petersen SB; Otzen DE, 2003. Trehalose favors a cutinase compact intermediate off-folding pathway.  Biochemistry 42(24):7611-7

Otzen DE, 2003. Folding of DsbB in mixed micelles: a kinetic analysis of the stability of a bacterial membrane protein.  J Mol Biol 330(4):641-9

Aachmann FL; Otzen DE; Larsen KL; Wimmer R, 2003. Structural background of cyclodextrin-protein interactions.  Protein Eng 16(12):905-12

Mogensen JE; Wimmer R; Larsen JN; Spangfort MD; Otzen DE, 2002. The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands.  J Biol Chem 277(26):23684-92

Otzen DE; Oliveberg M, 2002. Conformational plasticity in folding of the split beta-alpha-beta protein S6: evidence for burst-phase disruption of the native state.  J Mol Biol 317(4):613-27

Otzen DE; Oliveberg M, 2002. Burst-phase expansion of native protein prior to global unfolding in SDS.  J Mol Biol 315(5):1231-40

Otzen DE; Knudsen BR; Aachmann F; Larsen KL; Wimmer R, 2002. Structural basis for cyclodextrins' suppression of human growth hormone aggregation.  Protein Sci 11(7):1779-87

Pedersen JS; Otzen DE; Kristensen P, 2002. Directed evolution of barnase stability using proteolytic selection.  J Mol Biol 323(1):115-23

Otzen DE, 2002. Protein unfolding in detergents: effect of micelle structure, ionic strength, pH, and temperature.  Biophys J 83(4):2219-30

Otzen DE; Oliveberg M, 2001. A simple way to measure protein refolding rates in water.  J Mol Biol 313(3):479-83

Lindberg MO; Tångrot J; Otzen DE; Dolgikh DA; Finkelstein AV; Oliveberg M, 2001. Folding of circular permutants with decreased contact order: general trend balanced by protein stability.  J Mol Biol 314(4):891-900

Umakoshi H; Persson J; Kroon M; Johansson HO; Otzen DE; Kuboi R; Tjerneld F, 2000. Model process for separation based on unfolding and refolding of chymotrypsin inhibitor 2 in thermoseparating polymer two-phase systems.  J Chromatogr B Biomed Sci Appl 743(1-2):13-9

Cavallin A; Arozenius H; Kristensson K; Antonsson P; Otzen DE; Björk P; Forsberg G, 2000. The spectral and thermodynamic properties of staphylococcal enterotoxin A, E, and variants suggest that structural modifications are important to control their function.  J Biol Chem 275(3):1665-72

Otzen DE; Kristensen O; Oliveberg M, 2000. Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: a structural clue to amyloid assembly.  Proc Natl Acad Sci U S A 97(18):9907-12

Otzen DE; Fersht AR, 1999. Analysis of protein-protein interactions by mutagenesis: direct versus indirect effects.  Protein Eng 12(1):41-5

Otzen DE; Kristensen O; Proctor M; Oliveberg M, 1999. Structural changes in the transition state of protein folding: alternative interpretations of curved chevron plots.  Biochemistry 38(20):6499-511

Nielsen JE; Beier L; Otzen D; Borchert TV; Frantzen HB; Andersen KV; Svendsen A, 1999. Electrostatics in the active site of an alpha-amylase.  Eur J Biochem 264(3):816-24

Otzen DE; Oliveberg M, 1999. Salt-induced detour through compact regions of the protein folding landscape.  Proc Natl Acad Sci U S A 96(21):11746-51

Otzen DE; Christiansen L; Schülein M, 1999. A comparative study of the unfolding of the endoglucanase Cel45 from Humicola insolens in denaturant and surfactant.  Protein Sci 8(9):1878-87

Otzen DE; Fersht AR, 1998. Folding of circular and permuted chymotrypsin inhibitor 2: retention of the folding nucleus.  Biochemistry 37(22):8139-46

Neira JL; Itzhaki LS; Otzen DE; Davis B; Fersht AR, 1997. Hydrogen exchange in chymotrypsin inhibitor 2 probed by mutagenesis.  J Mol Biol 270(1):99-110

Tan YJ; Oliveberg M; Otzen DE; Fersht AR, 1997. The rate of isomerisation of peptidyl-proline bonds as a probe for interactions in the physiological denatured state of chymotrypsin inhibitor 2.  J Mol Biol 269(4):611-22

Otzen D; Riegels S, 1997. [Treatment of narcotic addiction--"fix" room causes less harm]. Interview by Jesper Berg].  Sygeplejersken 97(46):14-5

Daggett V; Li A; Itzhaki LS; Otzen DE; Fersht AR, 1996. Structure of the transition state for folding of a protein derived from experiment and simulation.  J Mol Biol 257(2):430-40

Otzen DE; Rheinnecker M; Fersht AR, 1995. Structural factors contributing to the hydrophobic effect: the partly exposed hydrophobic minicore in chymotrypsin inhibitor 2.  Biochemistry 34(40):13051-8

Matouschek A; Otzen DE; Itzhaki LS; Jackson SE; Fersht AR, 1995. Movement of the position of the transition state in protein folding.  Biochemistry 34(41):13656-62

Otzen DE; Fersht AR, 1995. Side-chain determinants of beta-sheet stability.  Biochemistry 34(17):5718-24

Ruiz-Sanz J; de Prat Gay G; Otzen DE; Fersht AR, 1995. Protein fragments as models for events in protein folding pathways: protein engineering analysis of the association of two complementary fragments of the barley chymotrypsin inhibitor 2 (CI-2).  Biochemistry 34(5):1695-701

Itzhaki LS; Otzen DE; Fersht AR, 1995. Nature and consequences of GroEL-protein interactions.  Biochemistry 34(44):14581-7

de Prat Gay G; Ruiz-Sanz J; Neira JL; Corrales FJ; Otzen DE; Ladurner AG; Fersht AR, 1995. Conformational pathway of the polypeptide chain of chymotrypsin inhibitor-2 growing from its N terminus in vitro. Parallels with the protein folding pathway.  J Mol Biol 254(5):968-79

Itzhaki LS; Otzen DE; Fersht AR, 1995. The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding.  J Mol Biol 254(2):260-88

Otzen DE; Itzhaki LS; elMasry NF; Jackson SE; Fersht AR, 1994. Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding.  Proc Natl Acad Sci U S A 91(22):10422-5

Otzen DE; Barciszewski J; Clark BF, 1994. Dual hydrolytic role for Pb(II) ions.  Biochimie 76(1):15-21

Fersht AR; Itzhaki LS; elMasry NF; Matthews JM; Otzen DE, 1994. Single versus parallel pathways of protein folding and fractional formation of structure in the transition state.  Proc Natl Acad Sci U S A 91(22):10426-9

Barciszewski J; Rattan SI; Siboska GE; Otzen DE; Clark BF, 1993. Reduction in the amount of 8-hydroxy-2'-deoxyguanosine in the DNA of SV40-transformed human fibroblasts as compared with normal cells in culture.  FEBS Lett 318(2):186-8

Otzen DE; Barciszewski J; Clark BF, 1993. Altered lead(II)-cleavage pattern of free Phe-tRNAPhe and Phe-tRNAPhe in ternary complex with EF-Tu:GTP.  Biochem Mol Biol Int 31(1):95-103

Barciszewski J; Otzen D; Rattan SI; Clark BF, 1992. Specific incorporation of kinetin into eukaryotic and prokaryotic transfer ribonucleic acid molecules.  Biochem Int 28(5):805-11

VAN SCHREVEN DA; OTZEN D; LINDENBERGH DJ, 1954. On the production of legume inoculants in a mixture of peat and soil.  Antonie Van Leeuwenhoek 20(1):33-57

VAN SCHREVEN DA; HARMSEN GW; LINDENBERGH DJ; OTZEN D, 1953. Experiments on the cultivation of Rhizobium in liquid media for use on the Zuiderzee polders.  Antonie Van Leeuwenhoek 19(4):300-8

Publication list retrieved from NCBI using ImpactPubs

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